Check Intently (one)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is often a strong inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for attainable dosage adjustments.nevirapine will lessen the extent or impact of diazepam by inf